Drafter / Verifier: PKM / RAH Prepared 2nd April 2015
ORAL BENZODIAZEPINE CONVERSION TABLE
|
Drug Name
|
Approximate Equivalent Dose‡
|
Therapeutic use
|
Time to Peak (Onset of action in hours)
|
Elimination
Half-Life (h)†
[active metabolite]
|
|
Alprazolam
|
0.5 mg
|
anxiolytic
|
1 – 2
|
9–20
|
|
Clobazam
|
20mg
|
anxiolytic,
anticonvulsant
|
0.5 – 4
|
12-60
|
|
Clonazepam
|
0.5 mg
|
anxiolytic,
anticonvulsant
|
1 – 4*
|
18–50
|
|
Diazepam
|
10 mg
|
anxiolytic,
anticonvulsant,
muscle relaxant
|
1 – 1.5
|
20–100
[36–200]
|
|
Lorazepam
|
1 mg
|
anxiolytic,
anticonvulsant
|
2 – 4
|
10–20
|
|
Midazolam
|
7.5 mg
|
hypnotic,
anticonvulsant
|
0.5 – 1
|
1.8 – 6
|
Adapted from Asthon H.
Benzodiazepine Equivalency Table (http://www.benzo.org.uk/bzequiv.htm#5)
‡Equivalent doses are based on clinical experience but may vary between individuals. †Half-life: time taken for blood concentration to fall to half its peak value after a single dose of active metabolite shown in [square bracket]. This time may vary considerably between individuals.
*Reference: Up-To-Date (www.uptodate.com) accessed on 2 Apr 2015 |
 Updating... Ċ Chong Ching Wern, Oct 26, 2015, 12:53 AM
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