> Oral Benzodiazepine Conversion Table

Drafter / Verifier: PKM / RAH
Prepared 2nd April 2015

        ORAL BENZODIAZEPINE CONVERSION TABLE

Drug Name

Approximate Equivalent Dose

Therapeutic use

Time to Peak (Onset of action in hours)

Elimination Half-Life (h) 
[active metabolite]

Alprazolam


0.5 mg

anxiolytic

1 – 2

9–20

Clobazam


20mg

anxiolytic,
anticonvulsant

0.5 – 4

12-60

Clonazepam


0.5 mg

anxiolytic, 
anticonvulsant

1 – 4*

18–50

Diazepam



10 mg

anxiolytic,
anticonvulsant, 
muscle relaxant

1 – 1.5

20–100
[36–200]

Lorazepam


1 mg

anxiolytic, 
anticonvulsant

2 – 4

10–20

Midazolam


7.5 mg

hypnotic, 
anticonvulsant

0.5 – 1

1.8 – 6

Adapted from Asthon H. Benzodiazepine Equivalency Table (http://www.benzo.org.uk/bzequiv.htm#5)

‡Equivalent doses are based on clinical experience but may vary between individuals. 

†Half-life: time taken for blood concentration to fall to half its peak value after a single dose of active metabolite shown in [square bracket]. This time may vary considerably between individuals.
*Reference: Up-To-Date (www.uptodate.com) accessed on 2 Apr 2015
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Chong Ching Wern,
Oct 26, 2015, 12:53 AM