The Universiti Malaya Medical Centre is proud to announce the release of the third edition of its Online Antimicrobial Guidelines, designed to promote judicious antimicrobial prescribing and to support our collective efforts in antimicrobial stewardship. This edition integrates the latest global evidence on antimicrobial treatments, ensuring that healthcare professionals are equipped with the most current knowledge to make informed decisions. Notably, it aligns with our hospital’s latest antibiogram, offering a tailored approach to addressing local resistance patterns. In a time where antimicrobial resistance continues to pose a significant threat to global public health, this guideline serves as a critical tool in combating the misuse of antimicrobials. It emphasizes best practices in treatment selection, proper dosing, and duration of therapy, aiming to curb the emergence of resistant organisms. Whether you are a clinician, pharmacist, or medical student, this guideline empowers you to be part of a collaborative effort in preserving the effectiveness of existing antimicrobials for future generations. Together, we can strengthen our stewardship efforts and combat the rising tide of antimicrobial resistance.